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| Env Domain | Signal peptide C1 V1 loop |
|---|---|
| HXBc2 Scale | : |10 : |20 : |30 : |40 : |50 : |60 : |70 : |80 : |90 : |100 : |110 : |120 : |130 : |140 : |
| HXBc2 Reference | MRVKE---KYQHLWRWGWRWGTMLLGMLMICSATEKLWVTVYYGVPVWKEATTTLFCASDAKAYDTEVHNVWATHACVPTDPNPQEVVLVNVTENFNMWKNDMVEQMHEDIISLWDQSLKPCVKLTPLCVSLKCTDLKNDTNTNSSSGRM |
| JRFL | ....GIRKN.....----.G..L...IIV....V.......................................................G....K......N.....Q......................T.N.K.VNATNT..--GSEG |
| ADA | .....--K-.........K.......I..............................................................E...........N............................T.N....R.V..I.---NSS |
| Env Domain | V2 loop C2 V |
|---|---|
| HXBc2 Scale | |150 : |160 : |170 : |180 : |190 : |200 : |210 : |220 : |230 : |240 : |250 : |260 : |270 : |280 : |290 : |
| HXBc2 Reference | IMEKGEIKNCSFNISTSIRGKVQKEYAFFYKLDIIPIDNDTTSYKLTSCNTSVITQACPKVSFEPIPIHYCAPAGFAILKCNNKTFNGTGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEEVVIRSVNFTDNAKTIIVQLNTSVEINCT |
| JRFL | T..R..........T....DE......L.....VV....NN...R.I..D..........I.....................D.....K...K..................................D...N.........KE....... |
| ADA | EGMR..........T....D..K.D..L..R..VV.....N...R.IN....T..................T.........KD.K.......K..................................S.......N.....KE....... |
| Env Domain | 3 loop C3 V4 loop C4 |
|---|---|
| HXBc2 Scale | |300 : |310 : |320 : |330 : |340 : |350 : |360 : |370 : |380 : |390 : |400 : |410 : |420 : |430 : |440 : |
| HXBc2 Reference | RPNNNTRKRIRIQRGPGRAFVTIGK-IGNMRQAHCNISRAKWNNTLKQIASKLREQFGNNKTIIFKQSSGGDPEIVTHSFNCGGEFFYCNSTQLFNSTWFNSTWS-TEGSNNTEGSDTITLPCRIKQIINMWQKVGKAMYAPPISGQIRC |
| JRFL | ........S.H.--......Y.T.EI..DI.............D.....VI......E-....V.NH.........M......................N.N.-----EGS.NTEGN................E..........R..... |
| ADA | ........S.H.--......Y.T.EI..DI.........T......N...T..K.........V.N..........M......................NFNGTWNLTQ..G...N.................E..........R..... |
| Env Domain | V5 loop C5 CS Fusion peptide HR1 |
|---|---|
| HXBc2 Scale | |450 : |460 : |470 : |480 : |490 : |500 : |510 : |520 : |530 : |540 : |550 : |560 : |570 : |580 : |590 |
| HXBc2 Reference | SSNITGLLLTRDGGNSNNESEIFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTKAKRRVVQREKRAVG-IGALFLGFLGAAGSTMGAASMTLTVQARQLLSGIVQQQNNLLRAIEAQQHLLQLTVWGIKQLQARILAVERYLKDQQLLG |
| JRFL | ..............INE.GT..........K......................................-...V........................L....................RM..............V.......G...... |
| ADA | .......I......TNSSG..................................................T...M................I.......L....................................V.......R...... |
| Env Domain | HR2 TM domain Cytoplasmic tail |
|---|---|
| HXBc2 Scale | : |600 : |610 : |620 : |630 : |640 : |650 : |660 : |670 : |680 : |690 : |700 : |710 : |720 : |730 : |740 |
| HXBc2 Reference | IWGCSGKLICTTAVPWNASWSNKSLEQIWNHTTWMEWDREINNYTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWFNITNWLWYIKLFIMIVGGLVGLRIVFAVLSIVNRVRQGYSPLSFQTHLPTPRGPDRPEGIEEEGGERDRDR |
| JRFL | .........................DR...NM.....E...D....E.YT.............................D..K......I........I......T...................L..A..................... |
| ADA | ...................................................................................................................................................... |
| Env Domain | |
|---|---|
| HXBc2 Scale | : |750 : |760 : |770 : |780 : |790 : |800 : |810 : |820 : |830 : |840 : |850 : |
| HXBc2 Reference | SIRLVNGSLALIWDDLRSLCLFSYHRLRDLLLIVTRIVELLGRRGWEALKYWWNLLQYWSQELKNSAVSLLNATAIAVAEGTDRVIEVVQGACRAIRHIPRRIRQGLERILL* |
| JRFL | .G.....F.....V..................T..............V....................................I..AL.RTY...L...T........A..- |
| ADA | ....................................................................N...................L.A.Y.................... |
Known Issues